Locked nucleic acid molecular beacons |
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| Authors: | Wang Lin Yang Chaoyong James Medley Colin D Benner Steven A Tan Weihong |
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| Affiliation: | Center for Research at Bio/nano Interface, Department of Chemistry, UF Genetics Institute, Gainesville, Florida 32611-7200, USA. |
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| Abstract: | A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies. |
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