Solid-state NMR spectroscopic study of the structure of grafted layers of phosphonic acid ester-modified hydroxyapatite |
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Authors: | P G Mingalyov Yu G Kolyagin G V Lisichkin |
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Institution: | (1) Department of Materials Science, Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapester Str. 27, 01062 Dresden, Germany;(2) Institute of Physiological Chemistry, Dresden University of Technology, Fiedlerstr. 42, 01307 Dresden, Germany;(3) Max Planck Institute for Chemical Physics of Solids, Nöthnitzerstr. 40, 01187 Dresden, Germany |
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Abstract: | Interaction of hydroxyapatite (HAP) surface with phosphonic acid esters is studied under different conditions. The urgency
of the study is due to the fact that HAP is one of the main components of bone tissue and is widely applied in the production
of materials designed for filling bone defects. Modification of the surface properties of HAP may result in the development
of materials with increased biocompatibility. It is revealed that, in the absence of solvents or in the medium of an aprotic
solvent, phosphonic acid esters interact with HAP surface to yield pyrophosphate groups. The interaction with the surface
does not take place in the presence of protic solvents. |
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