Highly efficient route for enantioselective preparation of chlorohydrins via dynamic kinetic resolution |
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Authors: | Träff Annika Bogár Krisztián Warner Madeleine Bäckvall Jan-E |
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Affiliation: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden. |
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Abstract: | Dynamic kinetic resolution (DKR) of various aromatic chlorohydrins with the use of Pseudomonas cepacia lipase (PS-C "Amano" II) and ruthenium catalyst 1 afforded chlorohydrin acetates in high yields and high enantiomeric excesses. These optically pure chlorohydrin acetates are useful synthetic intermediates and can be transformed to a range of important chiral compounds. |
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