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H Magnetic resonance imaging and P magnetic resonance spectroscopy in experimental filariasis |
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| Authors: | Amita Shukla-Dave Nigar Fatma Raja Roy S Srivastava RK Chatterjee V Govindaraju AKasi Viswanathan P Raghunathan |
| Institution: | a Division of Parasitology, Central Drug Research Institute, Lucknow, India b Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India c Division of Toxicology, Central Drug Research Institute, Lucknow, India d Department of NMR, All India Institute of Medical Sciences, New Delhi, India |
| Abstract: | 1H Magnetic resonance imaging and 31P magnetic resonance spectroscopy (MRS) have been carried out in experimental rodent filariasis, i.e., Acanthocheilonema viteae infection in the rodent host, Mastomys coucha. The T2-weighted image of the infected host shows fine hyperintense thread like structures of adult filariid nests in the cervical region. 31P MRS of normal and infected hosts, localized over the same region of interest, show seven major peaks corresponding to phosphomonoesters (including glucose-6-phosphate, fructose-6-phosphate, fructose-1-6-diphosphate, phosphorylcholine, and adenine monophosphate or AMP), inorganic phosphate, glycerophosphorylcholine, phosphoenolpyruvate, phosphocreatine and nucleoside di- and tri-phosphates. Concentrations of phosphomonoesters (PMEs) are higher in the normal rodent compared with the infected ones. In vivo 31P MRS provides a non-invasive assessment of tissue bioenergetics and phospholipid metabolism. |
| Keywords: | 1H Magnetic resonance imaging 31P Magnetic resonance spectroscopy Phosphorus metabolism Acanthocheilonema viteae Mastomys coucha filariasis |
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