Synthesis of (+/-)-epi-stegobinone utilizing silacyclopropanes as synthetic intermediates |
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Authors: | Calad Stacie A Ciraković Jelena Woerpel K A |
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Institution: | Department of Chemistry, University of California, Irvine, California 92697-2025, USA. |
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Abstract: | The synthesis of (+/-)-1'-epi-stegobinone has been accomplished in ten steps and 17% overall yield from a recently reported silacyclopropane-derived diol. All stereocenters of the final product were established relative to the stereochemistry of the initial silacyclopropane. This synthesis represents the first time silacyclopropane reactivity has been employed in a target-directed synthesis. |
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