Direct access to marine pyrrole-2-aminoimidazoles, oroidin, and derivatives, via new acyl-1,2-dihydropyridin intermediates |
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Authors: | Schroif-Gregoire Cosima Travert Nathalie Zaparucha Anne Al-Mourabit Ali |
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Institution: | Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France. |
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Abstract: | reaction: see text] A short synthesis of the C(11)N(5) oroidin derivatives is reported. The key step of the strategy is a one-pot oxidative bromine-mediated addition of protected guanidines to the N-acyl-1,2-dihydropyridines 9a-c. The new N-acyl-1,2-dihydropyridines were prepared directly from pyridine and pyrrole-2-carbonyl chloride by reduction with borohydride reagent in one step. |
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