| 新型β-希夫碱衍生化β-环糊精键合硅胶手性固定相的合成与色谱性能研究 |
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| 引用本文： | 方敏,周智明,罗爱芹.新型β-希夫碱衍生化β-环糊精键合硅胶手性固定相的合成与色谱性能研究[J].高等学校化学学报,2005,26(8):1443-1445. |
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| 作者姓名： | 方敏 周智明 罗爱芹 |
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| 作者单位： | 北京理工大学化工与环境学院,北京,100081 |
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| 基金项目： | 北京理工大学校科研和教改项目 |
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| 摘 要： | 环糊精及其衍生物在手性分离、模拟酶及手性催化剂药物转运等方面都有一定的应用，设计并合成新型的环糊精衍生物并扩大其应用范围是非常必要的。近年来，手性希夫碱作为配体已在不对称催化反应中有很好的应用，我们将手性希夫碱配体中的刚性C=N片断引入到环糊精中制成键合固定相，
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| 关 键 词： | 希夫碱 β-环糊精 高效液相色谱 |
| 文章编号： | 0250-0790（2005）08-1443-03 |
| 收稿时间： | 10 10 2004 12:00AM |
| 修稿时间： | 2004-10-10 |
Synthesis of Chiral Stationary Phases via Bonding β-cyclodextrin with α-Schiff Base and Chromatographic Performance |
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| FANG Min,ZHOU Zhi-ming,LUO Ai-qin.Synthesis of Chiral Stationary Phases via Bonding β-cyclodextrin with α-Schiff Base and Chromatographic Performance[J].Chemical Research In Chinese Universities,2005,26(8):1443-1445. |
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| Authors: | FANG Min ZHOU Zhi-ming LUO Ai-qin |
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| Institution: | School of Chemical Engineering and the Environment, Beijing Institute of Technology, Beijing 100081, China |
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| Abstract: | Two chiral stationary phases(BCDs and YBCDs) were prepared by bonding β-cyclodextrin derivative with α-Schiff base group from β-cyclodextrin monoaldehyde to the sillica gel via 3-glyci-dyloxypropyltrimethoxysilane as a coupling agent. Using acetonitrile-TEAA as mobile phase, good enantiomeric resolutions were obtained for DL-aminoacide on BCDs and YBCDs, including Leucine, Threonine and Valine. It is also observed that the higher separation factor of threonine was at pH {7.11} for both of the column, and the optimal column temperatures of Leucine appeared at 30 ℃ or 40 ℃, respectively for YBCDs and BCDs. |
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| Keywords: | Schiff base β-Cyclodextrin HPLC |
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