Facile,eco-friendly,catalyst-free synthesis of polyfunctionalized 2-aminopyrroles |
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| Institution: | 1. Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, No 866, Yuhangtang Road, Hangzhou, Zhejiang 310058, China;2. Torrey Pines Institute for Molecular Studies, Port St Lucie, FL 34987, USA;3. Morphology Laboratory, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;4. The First People’s Hospital of Jiande, Hangzhou, Zhejiang Province 311600, China;1. School of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China;2. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, PR China;1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone, 465 Biological Pharmaceutical Complex, Lexington, KY, 40536-0596, USA;2. Department of Molecular and Biomedical Pharmacology, and Graduate Center for Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, 40536, USA;1. Institute for Neurobiochemistry, Faculty of Medicine, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany;2. Department of Chemistry, Gonda-Goldschmied Medical Research Center, Bar-Ilan University, Ramat-Gan 52900, Israel;1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy;2. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen OE, Denmark |
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| Abstract: | Simple and eco-friendly synthesis of polyfunctionalized 2-aminopyrroles from vinyl azides and α-cyano derivatives has been accomplished with a good to excellent yield. The reaction was performed in ethanol/water co-solvent system without catalyst and the workup was facile. A plausible mechanism has been proposed. |
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