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Synthesis of amide libraries with immobilized HOBt |
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| Authors: | Smitha VokkaligaJeannie Jeong William R LaCourse Aristotle Kalivretenos |
| Institution: | a Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA b Aurora Analytics LLC, 1450 South Rolling Road, Baltimore, MD 21227, USA |
| Abstract: | Highly reactive N-acylating solid-phase reagents based on macroporous polystyrene-bound 1-hydroxybenzotriazole (P-HOBt) and silica-bound 1-hydroxybenzotriazole (Si-HOBt) were prepared and compared for reactivity by synthesis of small combinatorial libraries of acetamides and benzamides. |
| Keywords: | Combinatorial library Amide library Solid-phase synthesis Polymer-bound hydroxybenzotriazole |
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