Polymeric microspheres: a delivery system for osteogenic differentiation |
| |
| Authors: | Rajkumar Patel Madhumita Patel Jeonghun Kwak Arun K Iyer Rajshekhar Karpoormath Shrojal Desai Vimal Rarh |
| |
| Institution: | 1. School of Electrical and Computer Engineering, The University of Seoul, Seoul, Korea;2. Department of Chemistry and Nano Science, Ewha Womans University, Seoul, South Korea;3. Use‐inspired Biomaterials & Integrated Nano Delivery (U‐Bind) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health, Sciences, Wayne State University, Detroit, USA;4. Department of Pharmaceutical Chemistry, College of Health Sciences, University of Kwa Zulu Natal, Durban, Africa;5. Global Infusion Systems R&D at Hospira, Chicago, IL, USA;6. Department of Chemistry, S.G.T.B. Khalsa College, University of Delhi, Delhi, India |
| |
| Abstract: | Advanced drug delivery systems employing controlled release technology are being developed to address many of the difficulties associated with traditional methods of drug administration. Controlled release technology involves the use of devices such as polymer‐based disks, rods, pellets, or microspheres (MSs) that encapsulate drugs, genes, cytokines, and growth factors and release them in specific location within the body in a controlled fashion, for relatively long periods of time. Among these, microencapsulation is one of the core technologies used in polymer‐based drug delivery systems. In this regard, MS serves as microcarriers for sustain drug release facilitating their use for invasive or minimally invasive treatment. MS has significant potential for the application in bone repair, intra‐articular treatment of osteoarthritis, and biological bone growth. The present review compiles the recent advances in polymeric MS for application in bone and cartilage regeneration. Copyright © 2017 John Wiley & Sons, Ltd. |
| |
| Keywords: | microspheres bone regeneration PLGA fibroblast growth factor bone morphogenetic protein bone tissue engineering |
|
|
