A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs) |
| |
| Authors: | Collier Alice Wagner Gerd |
| |
| Institution: | Centre for Carbohydrate Chemistry, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UKNR4 7TJ. |
| |
| Abstract: | We report a simple and high-yielding two-step procedure for the preparation of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs). The key step of our synthesis is the Suzuki-Miyaura coupling of unprotected 8-bromo GMP and 8-bromo GTP with various arylboronic acids in aqueous solution. The 8-bromoguanosine 5'-phosphates required as cross-coupling substrates were prepared from 8-bromoguanosine via an optimised Yoshikawa procedure. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
