Synthesis and properties of Mg2Al layered double hydroxides containing 5-fluorouracil |
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Authors: | Zhongliang Wang Lei Gao Lin Xu |
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Affiliation: | Faculty of Chemistry, Institute of Polyoxometalate Chemistry, Northeast Normal University, Number 138, Renmin Street, Changchun City, Jilin Province 130024, P.R. China |
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Abstract: | A pharmaceutically active compound, 5-fluorouracil (5-FU) has been firstly intercalated into layered double hydroxide with the restructure method. Powder X-ray diffraction and spectroscopic analysis indicate that 5-FU molecule is stabilized in the host interlayer by electrostatic interaction and intermolecular interaction, and that the orientation of 5-FU is different when changing the pattern of aging treatment or the swelling agent. The release studies show that a rapid release of the drug during the first 40 min is followed by a more sustained one, and that the total amount of drug released from hybrid material into the aqueous solution is almost 87% and 74% at pH 4 and 7, respectively. The studies mentioned above suggest that layered double hydroxide might be used as the basis of a tunable drug delivery carrier. |
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Keywords: | Hydrotalcite Layered double hydroxide 5-Fluorouracil Hybrid material Controlled release |
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