| Studies on Agarofurans VIII. Synthesis of the Metabolites of 4-Butyl-a-agarofuran |
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| 作者姓名： | Chun Li Wu Yan Zhang Ji Yu Guo* Xiao Tian Liang Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing |
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| 作者单位： | Chun Li，Wu Yan Zhang，Ji Yu Guo*，Xiao Tian Liang Institute of Materia Medica，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100050 |
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| 摘 要： | Agarofurans have been found to be active on the nervous system in our institute. 4-Butyl-a-agarofuran 1 is a promising drug candidate. In order to explore the pharmacokinetics of 1, the metabolism of 1 in vitro was studied with liver microsomes from rats. Five metabolites were isolated and structures were identified as compounds 2-6. But the absolute configuration of 2,4,5 and the position of carbonyl in 3 could not be unambiguously determined. Further determination was limited by the smal…
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Studies on Agarofurans VIII. Synthesis of the Metabolites of 4-Butyl-a-agarofuran |
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| Chun Li,Wu Yan Zhang,Ji Yu Guo*,Xiao Tian Liang Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing .Studies on Agarofurans VIII. Synthesis of the Metabolites of 4-Butyl-a-agarofuran[J].Chinese Chemical Letters,2002,13(1). |
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| Authors: | Chun LI Wu Yan Zhang Ji Yu GUO Xiao Tian Liang |
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| Abstract: | The structures of five metabolites (2-6) of agarofuran 1 were confirmed by synthesis. The configuration of the secondary hydroxyl in 7 was determined by Horeau's method. The configuration of C-2 in compound 4 and 5 was determined by their stereochemistry and NMR. |
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| Keywords: | Agarofuran metabolite synthesis |
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