A Thermodynamic Study of Complexation of Iron Ions with Clarithromycin and Roxithromycin in Methanol Using a Conductometric Method |
| |
Authors: | Abdul-Wahab El-Rjoob Ziyad A Taha Jamil Al-Mustafa Abdulaziz M Ajlouni |
| |
Institution: | 1. Department of Applied Chemistry, Faculty of Arts and Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan
|
| |
Abstract: | The formation constants K ML of Clarithromycin (CLA) and Roxithromycin (ROX) with Fe(III) and Fe(II) ions in methanol have been determined at various temperatures using a conductometric technique. The interaction yields complexes with metal-to-ligand compositions of 1:1. The conductivity data were analyzed using a computer program based on 1:1 stoichiometry from which the stability constants and the limiting molar conductance were obtained. The stability of these complexes was found to increase with temperature. Compared with Fe(II), Fe(III) forms more stable complexes with ROX and CLA. The values of the thermodynamic parameters enthalpies (??H °), entropies (??S °), and the derived Gibbs energies (??G °) were deduced from the dependence of the formation constants on temperature. The positive values of ??H ° and ??S ° indicate that the complexation processes is enthalpically unfavorable but entropically favored. The negative values of ??G ° show the ability of the studied ligand to form stable complexes and that the complexation process is favorable. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|