Solvent Effects on Tautomeric and Microscopic Protonation Constants of Glycine in Different Aqueous Solutions of Methanol and Ethanol |
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Authors: | Ali Shamel Afsaneh Saghiri Fatemeh Jaberi Ali Farajtabar Faezeh Mofidi Saeid Abedini Khorrami Farrokh Gharib |
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Institution: | 1. Department of Chemistry, Ardabil Branch, Islamic Azad University, Ardabil, Iran 2. Department of Chemistry, Shahid Beheshti University, G. C., Tehran, Evin, Iran 3. Department of Chemistry, Jouybar Branch, Islamic Azad University, Jouybar, Iran 4. Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran
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Abstract: | The acid-base equilibria of glycine have been studied in different aqueous solutions of methanol and ethanol (0?C45?% v/v) using a potentiometric method. In this study, the macro and micro protonation constants of the amino acid and its tautomeric constant have been determined at 25?°C and constant ionic strength (0.1 mol?dm?3 NaClO4). The protonation and the tautomeric constants of glycine in different binary mixtures were analyzed in terms of the Kamlet, Abboud and Taft (KAT) parameters. Single-parameter correlations of the constants versus ?? (hydrogen-bond donor acidity), ?? (hydrogen-bond acceptor basicity) and ?? ? (dipolarity/polarizability) are poor in all solutions. Multi-parameter correlations show better results, but dual-parameter correlations represent significant improvements with regard to the single- and multi-parameter models. Linear correlation is observed when the experimental protonation constant values are plotted versus the calculated ones when the KAT parameters are considered. Finally, the results are discussed in terms of the effect of the solvent on protonation and tautomeric constants. |
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