Thiophenol-mediated 1,5-hydrogen transfer for the preparation of pyrrolizidines, indolizidines, and related compounds |
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| Authors: | Dénès Fabrice Beaufils Florent Renaud Philippe |
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| Affiliation: | Departement für Chemie und Biochemie, Universit?t Bern, Freiestrasse 3, 3012-Bern, Switzerland. |
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| Abstract: | The efficient preparation of 1-azabicyclic alkanes is described. Highly functionalized skeletons are prepared in a concise manner using a radical tin-free 1,5-hydrogen transfer-cyclization process. The precursors for the radical reactions are readily assembled either from pyrrolidine/piperidine/hexahydro-1H-azepine or via condensation of a properly designed N-alkylimine with an allenylzinc species. |
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