Crystalline inclusion complexes of diterpenoid isosteviol with aromatic compounds

Crystalline inclusion complexes of diterpenoid isosteviol (ent-16-ketobeyeran-19-oic acid) with individual benzene, o-, m-, p-xylenes, ethylbenzene, isopropylbenzene, o-and m-nitoranilins, benzaldehyde, styrene and naphthalene are obtained and characterized by single crystal X-ray diffraction. As determined by GC and ¹H NMR spectroscopy, isosteviol selectively includes toluene from the equimolar benzene-toluene mixture, o-xylene from a commercial mixture of xylenes, o-and m-nitroanilins from their mixture with p-nitroanilin, and also styrene from styrene-ethylbenzene and styrene-isopropylbenzene mixtures thus yielding crystalline inclusion complexes.