Atom‐Economic Synthesis of Fully Substituted 2‐Aminopyrroles via Gold‐Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles |
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| Authors: | Xin‐Yu Xiao Ai‐Hua Zhou Chao Shu Fei Pan Dr Ting Li Prof Dr Long‐Wu Ye |
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| Institution: | 1. State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, China;2. (+86)?592‐218‐5833;3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China |
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| Abstract: | A concise and flexible synthesis of fully substituted 2‐aminopyrroles via gold‐catalyzed formal 3+2] cycloaddition between ynamides and isoxazoles has been developed. Under mild reaction conditions, various 2‐aminopyrrole derivatives were obtained in good to excellent yields, thus providing an efficient and atom‐economic way for the construction of fully substituted 2‐aminopyrroles. |
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| Keywords: | 2-aminopyrroles cycloaddition gold homogeneous catalysis |
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