Surface-enhanced Raman scattering detection of lysophosphatidic acid |
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Authors: | Leo?Seballos Email author" target="_blank">Jin?Z?ZhangEmail author Rebecca?Sutphen |
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Institution: | (1) Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA;(2) Department of Interdisciplinary Oncology, College of Medicine and H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA |
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Abstract: | Surface-enhanced Raman scattering using silver nanoparticles was applied to detect various forms of lysophosphatidic acid
(LPA) to examine its potential application as an alternative to current detection methods of LPA as biomarkers of ovarian
cancer. Enhancement of the Raman modes of the molecule, especially those related to the acyl chain within the 800–1300 cm−1 region, was observed. In particular, the C–C vibration mode of the gauche-bonded chain around 1100 cm−1 was enhanced to allow the discrimination of two similar LPA molecules. Given the molecular selectivity of this technique,
the detection of LPA using SERS may eliminate the need for partial purification of samples prior to analysis in cancer screening. |
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Keywords: | Surface-enhanced Raman scattering Lysophosphatidic acid |
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