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Chiral Separation of Ibuprofen and Terbutaline by Nonaqueous Capillary Electrophoresis with Conductance Detection
Authors:DENG Guang-hui  WEI Shou-lian  MO Jin-yuan
Institution:1. Department of Chemistry, Guangxi University for Nationalities, Nanning 530006, P. R. China;
2. Department of Chemistry, Zhongshan University, Guangzhou 510275, P. R. China
Abstract:In the nonaqueous N,N-dimethylformamide medium, the chiral drugs ibuprofen and terbutaline were successfully separated with sulfonyl-β-cyclodextrin(s-β-CD) as the chiral selector by capillary electrophoresis with conductance detection. The comparison of the effects of three CDS(β-CD, diethylic-β-CD, sulfonyl-β-CD) on the chiral separation was made and the resolution mechanism was proposed.
Keywords:Nonaqueous medium  Capillary electrophoresis with conductance detection  Resolution  N  N-Dimethylformamide
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