Synthesis of the thiazole-thiazoline fragment of largazole analogues |
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| Authors: | Diness Frederik Nielsen Daniel S Fairlie David P |
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| Institution: | Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia. fdi@farma.ku.dk |
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| Abstract: | The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties. |
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