Annulation of furan-bridged 10-membered rings on N-heterocycles through [8+2] cycloaddition of dienylazaisobenzofurans and dimethyl acetylenedicarboxylate |
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Authors: | Priyabrata RoyBinay K. Ghorai |
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Affiliation: | Department of Chemistry, Bengal Engineering and Science University, Shibpur, Howrah 711 103, India |
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Abstract: | One-pot three-component coupling of o-alkynylheteroaryl carbonyl derivatives with α,β-unsaturated Fischer carbene complexes and dimethyl acetylenedicarboxylate leading to the synthesis of heterocyclic analogues of furanophane derivatives has been explored. This involves the generation of conformationally flexible dienylazaisobenzofuran intermediate as transient intermediates, which undergo [8+2] cycloaddition reaction with dienophile. In some cases, this intermediate undergoes twofold Diels-Alder reaction to afford heterolignan derivatives in a single step. |
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Keywords: | [8+2] Cycloaddition Dienylazaisobenzofurans Carbene complex Twofold Diels-Alder Heterolignan |
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