Regioselective ortho-acetoxylation/methoxylation of N-(2-benzoylphenyl)benzamides via substrate directed C-H activation |
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Authors: | BV Subba Reddy G RevathiA Srinivas Reddy JS Yadav |
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Institution: | Discovery Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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Abstract: | A highly regioselective ortho-acetoxylation of N-(2-benzoylphenyl)benzamides has been achieved using a catalytic amount of Pd(OAc)2 (10 mol %) and a stoichiometric amount of PhI(OAc)2 in a mixture of acetic anhydride and acetic acid via C-H activation to produce the corresponding 2-acetoxybenzamides in good yields. ortho-Methoxylation has been accomplished using methanol under similar conditions. |
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Keywords: | Pd(II) catalysis Hypervalent iodine Benzamide ortho-Acetoxylation/methoxylation Aromatic C-H activation |
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