| 牛膝菊中的萜类及甾醇类成分 |
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| 引用本文： | 潘争红,赵檑,黄荣,马国义,李祖强.牛膝菊中的萜类及甾醇类成分[J].云南大学学报(自然科学版),2007,29(6):613-616. |
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| 作者姓名： | 潘争红 赵檑 黄荣 马国义 李祖强 |
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| 作者单位： | 1. 云南大学,化学学院,云南,昆明,650091
2. 悉尼大学,药学系,澳大利亚 |
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| 摘 要： | 在细胞毒试验结果指导下,同步对牛膝菊(Galinsoga parviflora)全株的有效部位进行化学成分分离纯化,得到7个化合物,通过理化数据测定及波谱数据分析,鉴定了化学结构,分别是:对映-贝壳杉-16-烯-19-酸(1);对映-15-当归酰氧基-16-贝壳杉烯-19-酸(2);对映-15-当归酰氧基-16,17-环氧-19-贝壳杉烷酸(3);豆甾醇(4);α-菠甾醇(5);α-菠甾醇硬脂酸酯(6);β-谷甾醇(7).同时,细胞毒试验表明,牛膝菊的氯仿及乙酸乙酯提取物有一定细胞毒活性,其IC50分别为8.5,10.5μg/mL.
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| 关 键 词： | 牛膝菊 细胞毒性 萜烯 甾醇 |
| 文章编号： | 0258-7971（2007）06-0613-04 |
| 修稿时间： | 2007-07-02 |
Terpenes and sterols from Galinsoga parviflora |
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| PAN Zheng-hong,ZHAO Lei,HUANG Rong,MA Guo-yi,LI Zu-qiang.Terpenes and sterols from Galinsoga parviflora[J].Journal of Yunnan University(Natural Sciences),2007,29(6):613-616. |
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| Authors: | PAN Zheng-hong ZHAO Lei HUANG Rong MA Guo-yi LI Zu-qiang |
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| Institution: | 1. Experimental Center, Yunnan University, Kunming 650091, China; 2. Faculty of Pharmacy, the University of Sydney, NSW, Australia |
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| Abstract: | The chemical constituents of Galinsoga parviflora were studied.Seven compounds were isolated from G.parviflora by column chromatogramphies of sephadex LH-20 and silica gel.Their structures were identified by physical and chemical properties and spectral data analysis.All the seven compounds were isolated from this plant for the first time.These compunds are:ent-kaur-16-en19-oicacid,ent-15-angeloyloxy-16-kauren-19-oic-acid,ent-15-angeloyloxy-16,17-epoxy-19-kauranoicacid,stigmasterol,α-spinasterol,α-spinasterylqoctadecanate,β-sitostel.Cytotoxicity screening of the extracts from Galinsoga parviflora Cav was carried out by HL60 cell.Two extractive fractions obtained with chloroform and ethyl acetate possess anticancer activities.Their IC50 are 8.5,10.5μg/mL respectively. |
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| Keywords: | Galinsoga parviflora Cav cytotoxicity terpenes sterols |
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