One pot synthesis of unsymmetrical dihydropyridines by green,catalyst free and environmentally benign protocol |
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Abstract: | Abstract A facile and ecofriendly synthesis of β-enamino esters is reported by reaction of both aliphatic and aromatic amines with β-keto esters by refluxing in ethanol in absence of any catalyst. Addition of α,β-unsaturated aldehydes to the reaction mixture leads to the formation of unsymmetrical dihydropyridine derivatives which generally are metal free hydrogen sources for asymmetric reduction reactions. |
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Keywords: | β-enamino esters β-keto esters dihydropyridines α,β-unsaturated carbonyl compounds reflux |
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