Abstract: | Abstract A clean and operationally simple method has been developed for the preparation of mutual prodrug using paracetamol and various nonsteroidal anti-inflammatory drugs. The methodology involves use of TFAA/H3PO4 in acetonitrile and a variety of mutual prodrugs has been prepared in good yields by using this single-step C–O bond forming reaction. ![id=](/na101/home/literatum/publisher/tandf/journals/content/tgcl20/2012/tgcl20.v005.i03/17518253.2012.657251/production/images/medium/tgcl_a_657251_o_uf0011.gif) |