A green synthesis of 3,4-dihydropyrimidin-2-ones and 1,5-benzodiazepines catalyzed by Sn(HPO4)2.H2O nanodisks under solvent-free condition at room temperature

Abstract

Heterogeneous Tin (IV) hydrogen phosphate nanodisks Sn(HPO4)2.H2O] efficiently catalyzed the one-pot three component condensation of aromatic aldehydes, β-ketoesters and urea to produce 3,4–dihydropyrimidin-2-ones under solvent-free conditions at room temperature. Also, the catalyst is equally applicable for the preparation of 1,5–benzodiazepines under the same reaction conditions. The optimum load of the catalyst required is 10 mole% and reusable. Hence, the process is green.

Keywords:

Sn(HPO₄)₂.H2O nanodisks3,4-dihydropyrimidin-2-ones1,5-heterogeneous catalystsolvent-free condition

Acknowledgements

The authors thank the Director, Dr. P.G. Rao, HOD, Dr. J.C.S. Kataky, Synthetic Organic Chemistry Division and the Analytical Division of NEIST, Jorhat, Assam, India, for their help. P.H. thanks CSIR, New Delhi, for the research fellowship.