Microwave-assisted synthesis of novel spiro isoxazolidine derivatives

Abstract

α-N-substituted furan derivatives as new dipolarophiles have been employed in 1,3-dipolar cycloaddition reaction with α-chloro nitrones under microwave irradiation and found to afford exclusively novel regioselective 5-spiro cycloadducts with high yield in a very short reaction time.

Keywords:

α-N-substituted furan derivativesspiro isoxazolidinesregioselectivityMWI

Acknowledgements

Financial support from University Grants Commission, New Delhi (grant no:34-304/2008-SR) is gratefully acknowledged. We are also grateful to Dr M.P. Kharel, Principal, Sikkim Government College for providing facilities and also to Sophisticated Analytical Instrumentation Facility, Central Drug Research Institute, Lucknow for providing spectral data.