Molecular structures of some D-homo-6-oxa-8α analogs of steroidal estrogens

By X-ray crystallographic analysis and NMR spectroscopy it was demonstrated that the conformations of several D-homo-6-oxa-8α analogs of steroidal estrogens are similar in the crystal and in solution. The distances between the hydrogen atoms in these molecules, calculated by the ab initio and MM⁺ methods, correspond to the experimental data. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 202–207, February, 2008.