| 光敏剂在癌症诊断和治疗中的研究新进展 |
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| 引用本文： | 高源,乔光明,李娜,禚林海,唐波.光敏剂在癌症诊断和治疗中的研究新进展[J].分析化学,2011,39(12):1926-1931. |
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| 作者姓名： | 高源 乔光明 李娜 禚林海 唐波 |
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| 作者单位： | 山东师范大学化学化工与材料科学学院,教育部分子与纳米探针重点实验室,农药、医药中间体清洁生产教育部工程研究中心,济南250014 |
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| 基金项目： | 国家重点基础研究发展计划(973计划,No.2007CB936000); 国家杰出青年基金(No.20725518); 国家自然科学基金重点项目(No.21035003); 山东省科技发展计划项目(No.2008GG30003012); 山东省自然科学基金重点项目(No.ZR2010BZ001); 山东省高等学校科技计划项目(No.J10LB02)资助 |
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| 摘 要： | 光敏剂在特定波长的光照射下,产生荧光和单线态氧,已广泛应用于癌症的诊断和治疗.当前的研究热点是如何提高光敏剂的肿瘤选择性,尤其是光敏剂的靶向输送和特异性激活两方面.本文系统评述了提高光敏剂肿瘤选择性的方法及其在癌症诊断和治疗中的应用.引用文献56篇.
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| 关 键 词： | 光敏剂 荧光 单线态氧 肿瘤选择性 光动力学治疗 评述 |
Progress of Photosensitizer for Cancer Diagnosis and Therapy |
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| GAO Yuan,QIAO Guang-Ming,LI Na,ZHUO Lin-Hai,TANG Bo.Progress of Photosensitizer for Cancer Diagnosis and Therapy[J].Chinese Journal of Analytical Chemistry,2011,39(12):1926-1931. |
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| Authors: | GAO Yuan QIAO Guang-Ming LI Na ZHUO Lin-Hai TANG Bo |
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| Institution: | GAO Yuan,QIAO Guang-Ming,LI Na,ZHUO Lin-Hai,TANG Bo(College of Chemistry,Chemical Engineering and Materials Science,Key Laboratory of Molecular and Nano Probes,Ministry of Education,Engineering Research Center of Pesticide and Medicine Intermediate Clean Production,Shandong Normal University,Jinan 250014) |
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| Abstract: | Photosensitizer can generate fluorescence and singlet oxygen under irradiation of a specific wavelength of light,which is widely used in cancer diagnosis and therapy.It is a central research that focuses how to improve tumor selectivity of photosensitizer,especially in targeted-delivery and specific-activation.The recent research progress on improvement of tumor selecti-vity of photosensi-tizer and its application in cancer diagnosis and therapy is reviewed in this paper with 56 references. |
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| Keywords: | Photosensitizer Fluorescence Singlet oxygen Tumor selectivity Photodynamic therapy Review |
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