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A spirocyclic oxindole analogue:Synthesis and antitumor activities |
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| Authors: | Hui Hong Long Jiang Huang Da Wei Teng College of Chemical Engineering Qingdao University of Science & Technology Qingdao China |
| Affiliation: | College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao 266042, China |
| Abstract: | A new synthesis of spirocyclic oxindole analogue spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one 1 is described.The key steps involve dialkylation of arylacetonitrile and cyclization of the azaoxindole ring by an intramolecular Buchwald-Hartwig amidation of carboxylic ami Je and aryl chloride.A small library was obtained by reductive amination of 1 with various aldehydes and was screened against human lung cancer cell A549,human liver cancer cell BEL7402,and human colon cancer cell HCT-8.The result... |
| Keywords: | Spirocyclic oxindole Aryl amidation Dialkylation Antitumor activity |
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