Isolation, structure elucidation, and mutagenicity of four alternariol derivatives produced by the mangrove endophytic fungus No. 2240 |
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Authors: | Ni Tan Yiwen Tao Jiahui Pan Sanyong Wang Fang Xu Zhigang She Yongcheng Lin E B Gareth Jones |
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Institution: | (1) School of Chemistry and Chemical Engineering, Sun Yat-sen (Zhongshan) University, 510275 Guangzhou, P. R. China;(2) School of Chemistry and Chemical Engineering, University of South China, 421001 Hengyang, Hunan, P. R. China;(3) Department of Biology and Chemistry, City University of Hong Kong, Hong Kong, 999077, P. R. China |
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Abstract: | A new alternariol derivative, 2240B (1), together with alternariol (2), alternariol 4,10-dimethyl ether (3), and alternariol 4-methyl ether (4), was isolated from the ethyl acetate extract of the liquid medium GYT of No. 2240, the mangrove endophytic fungus from the
South China Sea Coast. The structure of compound 1 was unambiguously elucidated as alternariol 4-methyl-10-acethyl ester by spectra including one/two-dimensional NMR, HREIMS,
IR, and UV. The structures of compounds 2–4 were also established by spectroscopic analyses and comparison with related literature data. The anticancer tests showed
that compounds 2 and 4 had strong activities against KB and KBv200 cells with IC50 values of 3.17, 3.12, and 4.82, 4.94 μg/mL, while compounds 1 and 3 exhibited weak activities against the two kinds of tumor lines with IC50 values of more than 50 μg/mL.
Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 235–238, May–June, 2008. |
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Keywords: | alternariol derivatives mangrove endophytic fungus alternariol 4-methyl-10-acethyl ester mutagenicity KB tumor lines KBv200 |
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