Lectin-Mediated Drug Targeting: Discrimination of Carbohydrate-Mediated Cellular Uptake between Tumor and Liver Cells with Neoglycoconjugates Carrying Fucose Epitopes Regioselectively Modified in the 3-Position |
| |
Authors: | Lerchen Baumgarten Piel Kolb-Bachofen |
| |
Institution: | Bayer AG, Zentrale Forschung, Wirkstoff-Forschung, Geb?ude, D-51368 Leverkusen (Germany). |
| |
Abstract: | The circumvention of efficient "carbohydrate traps" in the liver is required for targeting glycoconjugates on tumor cells. As shown in the model system of bovine serum albumin (BSA) conjugates, the nature of R(1)-R(3) of the fucose epitope plays an important role in the discrimination of cellular uptake between tumor and liver cells as well as in the cytotoxic activity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|