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| Synthesis,Crystal Structure and Antitumor Activity in Vitro of a New Benzoate Binuclear Cupper（ Ⅱ） Complex | |
| 引用本文： | 康杰,黄细河,许建华,蒋智清,黄长沧. Synthesis,Crystal Structure and Antitumor Activity in Vitro of a New Benzoate Binuclear Cupper（ Ⅱ） Complex[J]. 结构化学, 2009, 28(1): 15-18 |
| 作者姓名： | 康杰 黄细河 许建华 蒋智清 黄长沧 |
| 作者单位： | KANG Jie(Department of Chemistry,Fuzhou University,Fudwu,Fujian 350002,China;College of Pharmacy,Fujian Medical University,Fuzhou,Fujian 350004,China);HUANG Xi-He,HUANG Chang-Cang(Department of Chemistry,Fuzhou University,Fudwu,Fujian 350002,China);XU Jian-Hua,JIANG Zhi-Qing(College of Pharmacy,Fujian Medical University,Fuzhou,Fujian 350004,China) |
| 基金项目： | 福建省自然科学基金，DAпCHI PHARMACEUTICAL(BEIJING)CO. |
| 摘 要： | The title compound, [Cu2（C7H5O2）4（C2H6O）2], was synthesized by the reaction of benzoic acid, copper acetate and ethanol in an aqueous solution. Trypan blue dye exclusion method was used in experiment. X-ray single-crystal analysis has revealed that compound 1 （C32H32Cu2O10） crystallizes in the monoclinic system, space group C2/c, Mr = 703.66, a = 47.340（5）, b = 6.6613（4）, c = 22.028（2）A,β = 113.284（4）°, V = 6380.6（10） A^3, Z = 8, Dc= 1.465 g/cm^3, F（000） = 2896,μ = 1.388 mm^-11, the final R = 0.0515 and wR = 0.1172 for 5712 observed reflections with I 〉 2σ（I）. X-ray crystal structure analysis suggests that compound [CH2（C7H5O2）4（C2H6O）2] has a binuclear structure with two Cu（II） atoms coordinated by four benzoate groups and two ethanol molecules. The crystal packing is stabilized by intermolecular O-H...O hydrogen bonds. The compound inhibits the proliferation of K562 cells （chronic myeloid leukemic cells） significantly and dose-dependently in 48 h, and IC50 of K562 is 17.3μg/mL by trypan blue dye exclusion method. |
| 关 键 词： | 双核铜(Ⅱ)配位化合物 晶体结构 合成 安息香酸盐 抗癌活性 |
Synthesis,Crystal Structure and Antitumor Activity in Vitro of a New Benzoate Binuclear CupperⅡ)Complex |
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| KANG Jie,HUANG Xi-He,XU Jian-Hua,JIANG Zhi-Qing,HUANG Chang-Cang. Synthesis,Crystal Structure and Antitumor Activity in Vitro of a New Benzoate Binuclear CupperⅡ)Complex[J]. Chinese Journal of Structural Chemistry, 2009, 28(1): 15-18 | |
| Authors: | KANG Jie HUANG Xi-He XU Jian-Hua JIANG Zhi-Qing HUANG Chang-Cang |
| Affiliation: | 1. Department of Chemistry,Fuzhou University,Fudwu,Fujian 350002,China;College of Pharmacy,Fujian Medical University,Fuzhou,Fujian 350004,China 2. Department of Chemistry,Fuzhou University,Fudwu,Fujian 350002,China 3. College of Pharmacy,Fujian Medical University,Fuzhou,Fujian 350004,China |
| Abstract: | The title compound，[Cu2(C7H5O2)4(C2H6O)2]，was synthesized by the reaction of benzoic acid，copper acetate and ethanol in an aqueous solution.Trypan blue dye exclusion method was used in experiment.X-ray single-crystal analysis has revealed that compound 1 (C32H32Cu2O10)crystallizes in the monoclinic system，space group C2／c，Mr=703.66，a=47.340(5)，b=6.6613(4)，C=22.028(2)(A)，β=113.284(4)°，V=6380.6(10)(A)3，Z=8，Dc=1.465 g／cm3，F(000)=2896，μ=1.388 mm-1，the final R=0.0515 and wR=O.1172 for 5712 observed reflections with I>2σ(I).X-ray crystal structure analysis suggests that compound [Cu2[C7H5Oz]4(C2H6O)2]has a binuclear structure with two Cu(п)atoms coordinated by four benzoate groups and two ethanol molecules.The crystal packing is stabilized by intermolecular O-H-O hydrogen bonds.The compound inhibits the proliferation of K562 cells(chronic myeloid leukemic cells)significantly and dose-dependently in 48 h,and IC50 of K562 is 17.μg／mL by trypan blue dye exclusion method. |
| Keywords: | crystal structure benzoate antitumor activity K562 |
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