| 健康和病变关节软骨的傅里叶变换红外光谱显微成像及Fisher判别 |
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| 引用本文： | 毛之华,张学喜,吴曰超,尹建华,XIA Yang. 健康和病变关节软骨的傅里叶变换红外光谱显微成像及Fisher判别[J]. 分析化学, 2015, 43(4): 518-522 |
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| 作者姓名： | 毛之华 张学喜 吴曰超 尹建华 XIA Yang |
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| 作者单位： | 1. 南京航空航天大学自动化学院生物医学工程系,南京,210016
2. Department of Physics and Center for Bimedical Reserch,Oakland University,Rochester,MI48309,USA |
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| 基金项目： | 国家自然科学基金(No.61378087);高等学校博士学科点专项科研基金(No.20133218120017)资助~~ |
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| 摘 要： | 傅里叶变换红外光谱显微成像(FTIRI)可同时获得样品的红外光谱和形貌信息,其与化学计量学方法结合,可实现生物组织中主成分含量及分布的定量研究.本研究采用FTIRI技术结合主成分分析(PCA)以及Fisher判别算法对正常和病变的关节软骨进行鉴别分析.对关节软骨切片进行实现FTIR扫描及光谱分析,再利用SPSS软件对软骨的光谱(矩阵)进行主成分分析,根据主成分得分矩阵构造分类函数,结合Fisher判别算法对样本进行分类识别.正常和病变的关节软骨样品识别准确率高达95.7％(初始案例)和94.3％(交互验证案例).本方法可准确有效地辨别关节软骨是否发生病变,为监测骨关节炎的发生和修复提供参考.
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| 关 键 词： | 关节软骨 傅里叶变换红外光谱 主成分分析 Fisher判别 |
Fourier Transform Infrared Microscopic Imaging and Fisher Discrimination for Identification of Healthy and Degenerated Articular Cartilage |
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| MAO Zhi-Hua , ZHANG XUE-XI , WU YUE-CHAO , YIN Jian-Hua , XIA Yang. Fourier Transform Infrared Microscopic Imaging and Fisher Discrimination for Identification of Healthy and Degenerated Articular Cartilage[J]. Chinese Journal of Analytical Chemistry, 2015, 43(4): 518-522 |
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| Authors: | MAO Zhi-Hua ZHANG XUE-XI WU YUE-CHAO YIN Jian-Hua XIA Yang |
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| Affiliation: | MAO Zhi-Hua;ZHANG XUE-XI;WU YUE-CHAO;YIN Jian-Hua;XIA Yang;Department of Biomedical Engineering,Nanjing University of Aeronautics and Astronautics;Department of Physics and Center for Bimedical Reserch,Oakland University; |
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| Abstract: | |
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| Keywords: | Articular cartilage Fourier transform infrared microscopy imaging Principal component analysis Fisher discrimination |
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