| 高效硅胶化学键合固定相的研究进展 |
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| 引用本文： | 佟巍,张养军,秦伟捷,钱小红.高效硅胶化学键合固定相的研究进展[J].色谱,2010,28(10):915-922. |
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| 作者姓名： | 佟巍 张养军 秦伟捷 钱小红 |
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| 作者单位： | 1. 蛋白质组学国家重点实验室, 军事医学科学院放射与辐射医学研究所, 北京蛋白质组研究中心, 北京 102206; 2. 中国人民武装警察部队医学院药学系, 天津 300162 |
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| 基金项目： | 国家重点基础研究规划项目(2006CB910803, 2007CB914104)、国家高技术研究发展计划项目(2006AA02A308, 2008AA02Z309)、国家自然科学基金项目(30621063, 20635010, 20735005, 20875101)、蛋白质组学国家重点实验室项目(SKLP-K200807, SKLP-O200808). |
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| 摘 要： | 对高效液相色谱用硅胶作为基质的化学键合固定相的研究进展进行了全面的评述。介绍了硅胶基质填料的物理化学性质及前处理过程,详细阐述了化学键合固定相的键合反应机制和种类,概括了化学键合固定相在高效液相色谱中的应用,并对我国的硅胶基质填料研究和应用前景进行了展望。
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| 关 键 词： | 高效液相色谱 硅胶基质填料 化学键合固定相 进展 |
| 收稿时间： | 2010-07-13 |
Recent advances of high performance chemically bonded silica gel stationary phases |
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| TONG Wei,ZHANG Yangjun,QIN Weijie,QIAN Xiaohong.Recent advances of high performance chemically bonded silica gel stationary phases[J].Chinese Journal of Chromatography,2010,28(10):915-922. |
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| Authors: | TONG Wei ZHANG Yangjun QIN Weijie QIAN Xiaohong |
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| Institution: | 1. State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing Proteome Research Center, Beijing 102206, China; 2. Department of Pharmacy, Medical College of Chinese People’s Armed Police Forces, Tianjin 300162, China |
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| Abstract: | The advances of the development and the application of silica packing medium in high performance liquid chromatography (HPLC) are reviewed. The physicochemical properties on surface and the methods of pre-processing of this medium are introduced. The bonding modes and the classes of chemically bonded stationary phase are described. The applications of silica packing medium in HPLC and its developing trends are also outlined. |
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| Keywords: | high performance liquid chromatography (HPLC) silica packing medium chemically bonded stationary phase advances |
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