Synthesis of N-(2-(Methylamino)ethyl) Derivatives of 2H-Phthalazin-1-ones |
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| Authors: | Zbigniew Malinowski Aleksandra K. Szcześniak Wanda Pakulska Dariusz Sroczyński Elżbieta Czarnecka Jan Epsztajn |
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| Affiliation: | 1. Faculty of Chemistry, Department of Organic Chemistry , University of ?ód? , ?ód? , Poland zbigmal@uni.lodz.pl;3. Faculty of Chemistry, Department of Organic Chemistry , University of ?ód? , ?ód? , Poland;4. Faculty of Pharmacy, Department of Pharmacodynamics , Medical University of ?ód? , ?ód? , Poland;5. Faculty of Chemistry, Department of Inorganic and Analytical Chemistry , University of ?ód? , ?ód? , Poland |
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| Abstract: | A series of new alkyl, tosyl, acetyl, and tert-butoxycarbonyl derivatives of 2-(2-aminoethyl)-phthalazinones were efficiently synthesized by reaction of lactams with N-Boc-, N-acetyl-, or N,O-ditosyl derivatives of N-methylethanolamine in the presence of MeONa or under Mitsunobu reaction conditions. Selected compounds were converted into corresponding 2-[2-(methylamino)ethyl]phthalazinones in good yields. |
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| Keywords: | Alkylation amines Mitsunobu reaction phthalazinones rotamers |
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