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ZrCl4-Catalyzed C-O Bond to C-N Bond Formation: Synthesis of 1,2,3-Triazoles and Their Biological Evaluation |
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| Authors: | Gangavaram V M Sharma Kandikonda Suresh Kumar Buddana Sudheer Kumar Sheri Venkata Reddy Reddy Shetty Prakasham Helmut Hugel |
| Institution: | 1. Organic and Biomolecular Chemistry Division, CSIR Indian Institute of Chemical Technology , Hyderabad , India;2. Organic and Biomolecular Chemistry Division, CSIR Indian Institute of Chemical Technology , Hyderabad , India;3. Biochemical and Environmental Engineering Sciences, CSIR Indian Institute of Chemical Technology , Hyderabad , India;4. Biochemical and Environmental Engineering Sciences, CSIR Indian Institute of Chemical Technology , Hyderabad , India;5. Royal Melbourne Institute of Technology , Melbourne , Australia |
| Abstract: | A simple and efficient protocol was developed for the synthesis of aryl azides directly from aryl carbinols using ZrCl4 as a Lewis acid catalyst. The azides were converted to novel triazoles under click reaction conditions, which were evaluated for their antimicrobial activity against various strains. |
| Keywords: | Antimicrobial activity click chemistry 1 2 3-triazole zirconium(IV) chloride |