Influence of Nano-Bioactive Glass (NBG) Content on Properties of Gelatin-Hyaluronic Acid/NBG Composite Scaffolds |
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| Authors: | Zhihua Zhou Siliang He Baoli Ou Tianlong Huang Wennan Zeng Lihua Liu |
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| Affiliation: | 1. Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan University of Science and Technology, Xiangtan, P. R. China;2. Hunan Province College Key Laboratory of QSAR/QSPR, Hunan University of Science and Technology, Xiangtan, P. R. China;3. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China;4. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China;5. Department of Orthopedics, the Second Xiangya Hospital, Central South University, Changsha, P. R. China |
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| Abstract: | The development of three-dimensional (3-D) scaffolds with highly open porous structure is one of the most important issues in tissue engineering. A novel nanocomposite scaffold of gelatin (Gel), hyaluronic acid (HA), and nano-bioactive glass (NBG) was prepared by blending NBG with a Gel and HA solution followed by lyophilization. The effects of NBG content on the properties of the Gel-HA/NBG composite scaffolds, including the morphologies, porosity, compressive strength, swelling behavior, cell viability and alkaline phosphatase (ALP) activity, were investigated. Porous composite scaffolds with interconnected pores were obtained and the pores became cylindrical with increasing NBG content. The porosity percent and swelling ability decreased with increasing NBG content; however, the compressive strength, cell viability and ALP activity were enhanced. All the results showed the addition of NBG particles can improve the physicochemical and biological properties and the Gel-HA/NBG composite scaffolds exhibited good potential for tissue engineering applications. |
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| Keywords: | composite scaffold gelatin hyaluronic acid nano-bioactive glass property |
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