Novel Four-Step Synthesis of Thioxo-quinazolino[3,4-a]quinazolinone Derivatives |
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Authors: | Behnaz Shafii Mina Saeedi Mohammad Mahdavi Alireza Foroumadi |
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Institution: | Department of Medicinal Chemistry , Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences , Tehran , Iran |
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Abstract: | A novel synthesis of thioxo-quinazolino3,4-a]quinazolinone framework was developed through a four-step reaction starting from isatoic anhydride. The resulting 2-aminobenzamides from the reaction of isatoic anhydride and different amines underwent coupling–cyclization reaction with 2-nitrobenzaldehydes, reduction of nitro group, and then cyclization reaction with carbon disulfide (CS2). All steps were carried out under easy and user-friendly conditions in a short time without using expensive catalysts or reagents. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
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Keywords: | Carbon disulfide (CS2) heterocycles 2-nitrobenzaldehydes thioxo-quinazolino[3 4-a]quinazolinone |
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