Synthesis,Antibacterial, and Antifungal Activities of Imidazo[2,1-c][1,2,4]triazoles and 1,2,4-Triazolo[4,3-a]pyrimidinones |
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| Authors: | Monia Aouali Imen Zouari Dhekra Mhalla Mohamed Trigui Fakher Chabchoub |
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| Affiliation: | 1. Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères , Faculté des Sciences de Sfax, Université de Sfax , Sfax , Tunisia;2. Biopesticides Team (LPIP) , Center of Biotechnology of Sfax, University of Sfax , Sfax , Tunisia |
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| Abstract: | A straightforward method has been developed for the synthesis of 1-phenyl-imidazo [2,1-c][1,2,4]triazole derivatives 5a–j and 1-phenyl-[1,2,4]triazolo[4,3-a]pyrimidinones derivatives 6a–g starting from 5-amino-1-phenyl[1,2,4]triazole and p-toluenesulfonic acid (PTSA). This methodology affords a number of 1-phenyl-imidazo [2,1-c][1,2,4]triazoles 5a–j and 1-phenyl-[1,2,4]triazolo[4,3-a]pyrimidinones 6a–g in reasonable yields and short reaction times. The structures of all new compounds were elucidated using infrared, 1H and 13C NMR, and high-resolution mass spectrometry. Some of the newly synthesized compounds were screened for their antimicrobial activity. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications ® for the following free supplemental resource(s): Full experimental and spectral details.] |
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| Keywords: | 5-Amino-1-phenyl[1,2,4]triazole antimicrobial activity imidazo[2,1-c][1,2,4]triazole triazolo[4,3-a] pyrimidinones |
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