One-Pot Synthesis of 2,3-Diarylbenzofurans via Sequential Iodocyclization and Pd-Catalyzed Suzuki Coupling Reactions of 2-Alkynylanisoles with Boronic Acids in Water |
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| Authors: | Jiang-Sheng Han Su-Qin Chen Ping Zhong |
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| Affiliation: | 1. College of Chemistry and Materials Engineering , Wenzhou University , Wenzhou , China;2. ShanDong WeGo Pharmaceutical Co. Ltd., Wego Group , Weihai , China;3. College of Chemistry and Materials Engineering , Wenzhou University , Wenzhou , China;4. Oujiang College, Wenzhou University , Wenzhou , China |
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| Abstract: | An efficient approach for the one-pot synthesis of 2,3-diarylbenzofurans via sequential iodocyclization and Pd-catalyzed Suzuki coupling reaction of 2-alkynylanisoles with boronic acids in water is reported. The protocol utilizes water as the solvent and there is no need to isolate the intermediate 3-iodine-2-arylbenzofurans, which exemplifies the ideal of green chemistry. Various 2-alkynylanisoles and boronic acids can participate in the reactions, providing a series of 2,3-diarylbenzofurans for drug discovery in moderate to good yields. |
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| Keywords: | 2-Alkynylanisole boronic acid 2,3-diarylbenzofuran iodocyclization palladium Suzuki coupling reaction |
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