Comparative Study of Catalytic Potential of TBAB,BTEAC, and CTAB in One-Pot Synthesis of 1,4-Dihydropyridines Under Aqueous Medium |
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| Authors: | T. Durai Ananda Kumar P. Mohan C. V. S. Subrahmanyam K. Satyanarayana |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry , Gokaraju Rangaraju College of Pharmacy , Hyderabad , Andhra Pradesh , India;2. Research and Development Cell , JNT University , Hyderabad , Andhra Pradesh , India;3. Department of Pharmaceutical Chemistry , Gokaraju Rangaraju College of Pharmacy , Hyderabad , Andhra Pradesh , India;4. Faculty of Pharmacy , Osmania University , Hyderabad , Andhra Pradesh , India;5. Natco Pharma Ltd. , Natco Research Center , Hyderabad , Andhra Pradesh , India |
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| Abstract: | Convenient and straightforward tetrabutylammonium bromide (TBAB), benzyltrienthylammonium chloride (BTEAC), and cetyltrimethylammonium bromide (CTAB) catalyzed synthesis of 1,4-dihydropyridines (1,4-DHPs) in water was established for the first time. The catalytic potential of phase-transfer catalysts (PTCs) in three different concentrations was envisioned. Aryl aldehydes and hetero aryl aldehydes afforded good yields of 1,4-DHPs in TBAB and BTEAC reactions. In particular, furfuraldehyde and thienyl-2-carbaldehyde produced excellent yields. Isolation of the products through nonchromatographic methods, good to excellent yields, and benign reaction conditions are the major advantages of this protocol. |
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| Keywords: | 1,4-Dihydropyridines Hantzsch reaction phase-transfer catalyst water reaction |
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