Ultrasound-Assisted,One-Pot,Four-Component Synthesis of 1,4,6,8-Tetrahydroquinolines in Aqueous Medium |
| |
| Authors: | Aisha Siddekha Sadeq Hamood Saleh Azzam |
| |
| Institution: | 1. Department of Studies in Chemistry , Bangalore University , Bangalore , India;2. Department of Chemistry , Smt. V. H. D Central Institute of Home Science , Bangalore , India;3. Department of Studies in Chemistry , Bangalore University , Bangalore , India |
| |
| Abstract: | A series of 2-amino-3-cyano-4-aryl-5-oxo-7,7-dimethyl-1,4,6,8-tetrahydroquinolines were prepared by a one-pot, four-component condensation of aromatic aldehydes, dimedone, malononitrile, and ammonium acetate using K2CO3 as a catalyst in aqueous medium under sonic conditions. This protocol, being a single-step reaction, has the advantages of operational simplicity and minimal environmental impact. The synthesized compounds were confirmed through spectral characterization using infrared, 1H NMR, 13C NMR, and CHN analysis. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
| |
| Keywords: | 2-Amino-3-cyano-4-aryl-5-oxo-7 7-dimethyl-1 4 6 8-tetrahydroquinolines aromatic aldehydes malononitrile potassium carbonate ultrasonication water |
|
|
