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Efficient Synthesis of Substituted Indene Derivatives
Authors:Sonia Taktouk  Jihène Ben Kraiem
Institution:Laboratory of Selective Organic Synthesis and Biological Activity, Faculty of Science , El Manar University , Tunis , Tunisia
Abstract:An efficient protocol for the synthesis of new functionalized indenes 3 was successfully realized. Thus the coupling reaction of allyl acetate 2 with Grignard reagents in the presence of a catalytic amount of LiCuBr2 at low temperature afforded pure ethyl 1-alkyl-1H-indenes-2-carboxylate 3 in good yields.
Keywords:Allylic acetates  ethyl 1-alkyl-1H-indenes-2-carboxylate  Grignard reagents  indenols
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