Highly Selective One-Pot Coupling Reaction of Indole,Aromatic Aldehydes,and 4-hydroxycoumarin Using Copper Octoate as a Homogeneous Catalyst |
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| Authors: | Farnoush Mousavizadeh Seyed Yahya Shirazi Beheshtiha Reyhaneh Rahnamafar |
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| Institution: | Department of Chemistry, School of Science , Alzahra University , Vanak , Tehran , Iran |
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| Abstract: | A facile protocol for the one-pot, multicomponent reaction of indole, 4-hydroxycoumarin, and aromatic aldehydes was developed using copper octoate as an inexpensive, commercially available, and efficient catalyst. This highly selective reaction eliminates the formation of homodimeric by-products (bisindoles and biscoumarins) and selectively results in the formation of heterodimeric adducts containing both indole and coumarin heterocycles. |
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| Keywords: | Copper octoate 4-hydroxycoumarin indole multicomponent reaction |
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