Pd-Catalyzed Reduction of Aldehydes to Alcohols Using Formic Acid as the Hydrogen Donor |
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| Authors: | Anwei Wang Zhiyong Yang Jidan Liu Qingwen Gui Xiang Chen |
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| Affiliation: | State Key Laboratory of Chemo/biosensing and Chemometrics , College of Chemistry and Chemical Engineering, Hunan University , Changsha , P. R. China |
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| Abstract: | Facile and selective reduction of aromatic aldehydes as well as aliphatic aldehydes to alcohols was achieved using formic acid as the hydrogen donor in the presence of a catalytic amount of Pd(OAc)2 and Cy3P. It was found that both hydrogen atoms in the formic acid molecule can serve as the hydride source. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
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| Keywords: | Aldehydes formic acid hydrogen transfer reduction palladium-catalyzed reduction |
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