Bi(OTf)3-Catalyzed Intramolecular Amination of Triazenylaryl Allylic Alcohols: A Stereoselective,High-Yield Synthesis of (E)-3-Alkenyl 2H-indazoles |
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| Authors: | Weijun Yang Zhigen Yang Lijun Xu Lili Zhang Xin Xu Maozhong Miao |
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| Institution: | 1. Department of Chemistry , Zhejiang University , Hangzhou , China;2. Department of Chemistry , Zhejiang Sci-Tech University , Hangzhou , China |
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| Abstract: | An efficient Bi(OTf)3-catalyzed synthesis of 3-alkenyl-2-pyrrolidine-2H-indazoles from triazenylaryl allylic alcohols via the intramolecular direct amination process is reported. Compared with the dodecyl benzenesulfonic acid (DBSA)-catalyzed method, the new method is more efficient and gives greater yields and functionality tolerance. Additionally, the 3-alkenyl-2-pyrrolidine-2H-indazoles can be transformed to a series of new products under different reaction conditions. |
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| Keywords: | Alkenyl 2H-indazole amination bismuth triflate triazenylaryl allylic alcohols |
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