Copper-Catalyzed Aerobic Oxidation for the Amination of Benzoxazole Under Air |
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| Authors: | Ke Cao Jia-Ling Wang Lin-Hui Wang Yuan-Yuan Li Xing-Hua Yu Yawen Huang |
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| Institution: | School of Materials Science and Engineering and State Key Laboratory Cultivation Base for Nonmetal Composite and Functional Materials , Southwest University of Science and Technology , Mianyang , China |
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| Abstract: | A practical copper-catalyzed aerobic oxidation for the amination of benzoxazole with secondary amine has been discovered. This reaction has proved to be effective to a variety of amines with lower catalyst loading amount, and only oxygen in air is required to facilitate this transformation. A copper-catalyzed/amine-induced ring opening of the benzoxazole and recyclization mechanism was also proposed. |
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| Keywords: | Aerobic oxidation air amination benzoxazole copper |
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