Catalysis by Amberlyst A-21: A Greener Approach to 4,5,6,7-Tetrahydro-1H-indazol-3(2H)-ones via Construction of Cyclohexanones |
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| Authors: | Manam Sreenivasa Rao Meda Haritha Sunder Kumar Kolli |
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| Institution: | 1. C.R.College, Ganapavaram , Chilakaluripet , Andhra Pradesh , India;2. Department of Pharmacy , Krishna University , Machilipatnam , Andhra Pradesh , India;3. Department of Chemistry , Acharya Nagarjuna University , Guntur , Andhra Pradesh , India |
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| Abstract: | The 4,5,6,7-tetrahydro-1H-indazol-3(2H)-one derivatives have been synthesized in good yields via a two-step method in a single pot. The initial step involved the construction of cyclohexanone ring from aromatic aldehydes and β-ketoester in i-PrOH using an inexpensive and reusable catalyst (i.e., Amberlyst A-21) under mild reaction conditions. The utility of this catalyst has been demonstrated in synthesizing a range of cyclohexanone derivatives. The catalyst can be recovered and recycled, which makes this procedure simple, convenient, economically viable, and environmental friendly. Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] |
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| Keywords: | Amberlyst A-21 catalysis cyclohexanone indazole |
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